Gabapentin Enacarbil Extended-Release: Evaluating Efficacy in Alcohol Use Disorder - Free Paper

Published: 2023-12-25
Gabapentin Enacarbil Extended-Release: Evaluating Efficacy in Alcohol Use Disorder - Free Paper
Essay type:  Analytical essays
Categories:  Research Disorder
Pages: 7
Wordcount: 1682 words
15 min read
Tittle: Gabapentin Enacarbil Extended–Release for Alcohol Use Disorder

The article's title is effective because it suggests key variables and the study population. The title builds the reader's curiosity to go through the research process. The illustration of key variables and the study population has allowed the title to support the major hypothesis. For example, the reader can predict that the article focuses on enhancing safety and well-being by choosing the right medication for alcohol use disorder (Falk et al., 2019). From this perspective, the title successfully plays its primary role – drawing the reader's attention and influencing them to read the article.

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The abstract clearly and concisely summarizes the main aspects of the report. The abstract allows the reader to determine the article's relevance by communicating key findings. Thus, a reader without enough time to read the entire article can grasp key ideas. For example, the reader understands the research method and analysis, which determines the article's relevance. Furthermore, the abstract has clearly stated keywords that reveal the main ideas of the article. The abstract has also utilized minimal words, encouraging the reader the go through the entire text and grasp key ideas.


The introduction is relevant to the title; therefore, it has unambiguously stated the problem. The reader can easily identify the problem and relate it to the title and nursing field. For instance, the instruction describes alcohol use disorder and its medication safety concerns, as stated in the title (Falk et al., 2019). This way, the introduction provides a positive first impression and establishes credibility with the reader, building a persuasive argument. The introduction prepares the reader for the article since they understand its overview. Thus, the introduction can be considered as an appropriate quantitative approach to describe the problem and relate it to nursing.


Although the article does not clearly state the hypothesis, the abstract reveals it by introducing the title. According to Coughlan et al. (2017), the first few paragraphs of an article often provide the hypothesis by explaining the research's primary purpose. In this sense, the hypothesis is not always well-stated; the reader has to go through the abstract to determine what the author emphasizes. From this perspective, the article's hypothesis is consistent with the literature review and the conceptual framework, based on the title and abstract.

Literature Review

The literature review is up to date because the author has used the latest sources to support arguments and draw evidence. Coughlan et al. (2017) argue that a good literature review does not simply describe or summarize the article but illustrates a pose that leads to a conclusion. In this regard, the literature review synthesizes and enhances an understanding of the title. The review identifies areas of prior scholarship to avoid duplication, giving credit to the researchers, and drawing a new study basis.

Conceptual Framework

The article defines key concepts conceptually by illustrating the reader's expectations. The conceptual framework describes the relevant variables for the article and shows how they relate to each other. For example, the reader can realize the effects of improper medication on alcohol use disorders. Alcohol-related consequences and their medication are a critical theoretical framework for the article, as the author establishes some rules, facts, and principles to obtain accurate results. For example, several alcohol users are observed for different periods to draw a reasonable comparison of alcohol-related consequences.

Method: Protection of Human Rights

The article employs an appropriate procedure to safeguard the human rights of the participants. The conceptual framework helps the researcher in identifying indicators for human rights assessment, using an effective methodological approach to populate the indicators with meaningful data. For instance, men and women who met DSM-5 criteria were provided with medication to promote their safety and well-being (Falk et al., 2019). In this sense, the article's methodology complied with nursing ethical standards. The methodological approach helped the study minimize risks and maximize benefits to participants by offering medication. Participants who revealed alcohol use disorder symptoms were treated using the right medication.

Research Design

The study used the most rigorous design to meet its primary purpose. Randomized controlled experiments helped the researcher to determine behavioral interventions for people with alcohol use disorder. For instance, participants were given 600 mg of double-blind GE-XR twice a day or a computerized behavioral intervention for six months (Falk et al., 2019). These different medications allowed the researcher to compare the results and conduct efficacy analyses after a four-week treatment period (Falk et al., 2019). Thus, data collection points were appropriate since the experiments were given enough time to provide accurate results. The design minimized biases and threats to the internal, external, and construct validity of the study by using the double-blind GE-XR.

Population and Sample

The study describes the population and sample appropriately in the research method. People who use alcohol are the study population, while the sample involved 346 people, both men and women (Falk et al., 2019). However, the research sampling design used does not enhance the sample's representatives because a reader cannot identify the number of male and female participants. Therefore, the sampling might have a sampling bias. Despite the representative inefficiency, the sampling size was adequate because the research could analyze and estimate its needs.

Data Collection and Measurements

The study uses experimental research that requires the researcher to adhere to scientific research design strictly. In this case, the researcher gives participants different medications to determine particular treatments' efficacy and safety (Falk et al., 2019). Key variables are operationalized using appropriate experiments that align with the study's primary purpose. Specific instruments, such as DSM-5 criteria, effectively determined participants who used large amounts of alcohol and chose their treatment. In this regard, the DSM-5 shows that the data collection methods yielded reliable and valid data.


The article reveals a computerized behavioral intervention for treating participants who were diagnosed with alcohol use disorder. The intervention is adequately described throughout the randomized control trials that allow the researcher to test different random-order interventions (Falk et al., 2019). However, the research does not draw evidence of whether the participants allocated to the intervention received it. Despite the lack of intervention evidence, the staff who collected data were appropriately trained – they were medical professionals.


The study conducts analyses to address each research question. It uses the test of statistical inference to determine the safety and efficacy of particular alcohol use disorders ((Falk et al., 2019). Qualitative research methods support the study's statistical analysis. For example, the samples suggest that 28.3 percent of the population consists of people with the disorder. The study uses appropriate statistical methods, descriptive and inferential analysis, to compare the results. The descriptive and inferential analytic methods were most effective because they helped the researcher control the confounding variables. Most importantly, Type 1 and Type 2 errors have been avoided as the study uses a low alpha and beta value. The intervention performed the intention-to-treat analysis by analyzing participants according to their original group assignment. The analysis facilitates a meta-analysis by using quantitative methods that provide sufficient information, useful for EBP.

Discussion: Interpretation of the Findings

The study interprets all major findings and discusses them within the context of the conceptual framework. Thus, the reader can understand the research process and recognize the relevancy of the findings. The study focuses on evidence-based research; therefore, it does not involve causal inferences. However, the interpretations are well-founded and align with the study's limitations. In this regard, the article addresses the issues of the findings' generalizability. The findings are based on qualitative research that draws relevant evidence and detailed information to respond to the research problem.


The study discusses some implications of the results for clinical practice. It explains the safety and efficacy of particular medications for alcohol use disorder (Falk et al., 2019). For instance, the study suggests that 600 mg of GE-XR twice a day is not efficient in reducing alcohol consumption or craving in people with AUD. This implication is useful in the clinical setting since healthcare professionals can avoid prescribing the medication. The finding is also useful for clinical policy development; healthcare professionals can apply the implication in implementing particular interventions for treating the disorder. They can use IR formulation rather than GE-XR since it showed efficacy in fewer trials at a higher dose (Falk et al., 2019).

Global Issues: Presentation

The report is well-written, organized, and detailed to provide critical analysis. More importantly, the study is based on scientific methods, like observing the clinical experiments and the theoretical framework analysis. The study has also tested the hypothesis using specific variables that lead to relevant findings and conclusions. The CONSORT flow diagram describes the interventions and shows the flow of participants in the study. For example, the reader can recognize that the study involved two main groups that tested various medications' safety and efficacy (Falk et al., 2019). The findings are accessible, as the author uses subheadings to streamline and clarify the report, to help the reader identify key points.

Researcher Credibility

The researcher's methodologic qualifications enhance findings and interpretation confidence. The study uses quantitative research methods that draw relevant evidence to support arguments. According to Coughlan et al. (2017), findings that arise from qualitative research often have relevant evidence, which is useful in decision-making. Furthermore, the study interprets the findings using appropriate indicators of measurement. In this way, the researcher has avoided the sole reliance on hypothesis testing by using the right values to convey detailed quantitative information. The theoretical framework and experiments have also enhanced confidence in interpreting the findings. Thus, the interpretation has allowed the researcher to gather relevant information on the topic of study, fulfilling the primary purpose of the study.

Summary Assessment

The study findings seem valid because they can be applied in the clinical setting. According to HHS (2019), healthcare professionals should choose the most appropriate treatment option for alcohol use disorder. A combination of treatments may work best for some people, while others require specific medication. In this regard, the study conducts various experiments to determine the safety and efficacy of particular treatments (Falk et al., 2019). It also recommends particular outpatient programs useful for people with less alcohol consumption effects (HHS, 2019).

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